With the new OEPE 18.104.22.168 you can create and run all your WLST scripts from Eclipse. This blogpost will give you a WLST jumpstart in the Eclipse IDE. The WLST / Phyton support for the Eclipse IDE is one of the many new OEPE features. For more info read the Markus Eisele great blogpost about all the new and cool features of OEPE.
Let's do some WLST scripting. Before you can start you need to download and install WebLogic. Off course you also need to download OEPE 22.214.171.124
Start Eclipse and provide the workspace folder.
Select the wlst folder and create a new WLST Script.
Change the domain folder in /user_project/domains/...
Next step is to start this WebLogic Domain. Select New and go to the Server node and click on Next.